Xbira 250mg Abiraterone Acetate Tablet

Introduction to Xbira 250mg Abiraterone Acetate Tablet

Xbira 250mg Abiraterone Acetate Tablet is a medication primarily used in the treatment of prostate cancer. This tablet works by inhibiting the production of androgens (male hormones) within the body, which are known to stimulate the growth of prostate cancer cells. By blocking this process, Xbira helps slow down the progression of cancer and may also reduce symptoms associated with advanced prostate cancer.

Patients typically take Xbira 250mg once daily on an empty stomach, usually in combination with prednisone or prednisolone to further decrease the production of adrenal androgens. It’s essential for patients to follow their doctor’s instructions carefully regarding dosage and administration to maximize its effectiveness and minimize potential side effects.

What is the Use of Xbira 250mg Pills?

Xbira 250mg pills, which contain Abiraterone Acetate, are primarily used for the treatment of prostate cancer. Specifically, they are indicated for:

• Metastatic Prostate Cancer: Xbira is used in combination with prednisone or prednisolone in patients with metastatic castration-resistant prostate cancer (mCRPC) who have previously received chemotherapy containing docetaxel.
• Hormone-Sensitive Prostate Cancer: In some cases, Xbira may also be prescribed in combination with prednisone or prednisolone for the treatment of metastatic hormone-sensitive prostate cancer (mHSPC), particularly in patients who are at high risk of developing symptoms related to their disease.

The medication works by inhibiting the enzyme CYP17, which is involved in the production of androgens (male hormones) in the body. By blocking this enzyme, Xbira helps reduce the levels of androgens that can stimulate the growth of prostate cancer cells, thereby slowing down the progression of the disease.

How Does the Xbira 250mg Abiraterone Acetate Tablet Work?

Xbira 250mg Abiraterone Acetate Tablet works by targeting and inhibiting an enzyme called CYP17 (17α-hydroxylase/C17,20-lyase). This enzyme plays a crucial role in the synthesis of androgens (male hormones) in the body, including testosterone and dihydrotestosterone (DHT).

In prostate cancer, particularly in its advanced stages such as metastatic castration-resistant prostate cancer (mCRPC), cancer cells often continue to depend on androgens for growth and survival despite standard hormonal therapies that aim to lower androgen levels. Xbira acts by inhibiting CYP17, thereby blocking the production of androgens both within the testes and adrenal glands. This reduction in androgen levels helps to deprive prostate cancer cells of the hormones they need to grow and proliferate.

Side Effects of Xbira 250mg (Abiraterone AcetateTablet)

Xbira 250mg (Abiraterone Acetate Tablet) may cause several side effects, which can vary in severity and frequency among individuals. Common side effects include:

• Fatigue
• Joint Swelling or Pain
• Hot Flashes
• Gastrointestinal Issues
• Liver Function Abnormalities
• Cardiac Disorders

Drug Interactions

Xbira 250mg Tablet (Abiraterone Acetate) can interact with several drugs, potentially altering their effectiveness or increasing the risk of side effects. Some important drug interactions include:

• Corticosteroids
• Anticoagulants
• Anticonvulsants
• Antiarrhythmics
• Antihypertensives
• Drugs Metabolized by CYP3A4
• Gastric Acid Reducing Agents

Manufacturer

Storage

The storage guidelines for Xbira 250mg Tablet (Abiraterone Acetate) are typically as follows:

• Room Temperature
• Avoid Moisture
• Original Packaging
• Keep Out of Reach
• Do Not Freeze

Dosages

Xbira 250mg Tablet (Abiraterone Acetate) is prescribed in specific dosages primarily for the treatment of advanced prostate cancer. The recommended dosage for most patients with metastatic castration-resistant prostate cancer (mCRPC) is 1,000 mg once daily, taken orally. This typically involves taking four tablets of Xbira 250mg each. It’s important to administer Xbira on an empty stomach, either at least one hour before or two hours after a meal, to optimize absorption.

The treatment is often combined with low-dose corticosteroids such as prednisone or prednisolone to further reduce adrenal androgen production. This combination therapy is crucial for enhancing the effectiveness of Xbira in lowering androgen levels, which are essential for prostate cancer growth. Patients are advised to adhere strictly to the prescribed dosing schedule to maintain consistent drug levels in the bloodstream, thereby maximizing therapeutic benefits.

Warning And Precaution

When using Xbira 250mg Tablet (Abiraterone Acetate), it’s important to be aware of several warnings and precautions to ensure safe and effective treatment. Here are key considerations:

1. Hepatotoxicity:

• Xbira can cause liver enzyme elevations and liver function abnormalities. Liver function tests should be monitored before starting treatment, every two weeks for the first three months of treatment, and monthly thereafter. Patients with pre-existing liver disease or elevated baseline liver enzymes may require more frequent monitoring.

2. Adrenal Insufficiency:

• Xbira lowers adrenal androgen levels, which can lead to adrenal insufficiency, especially when used concurrently with corticosteroids like prednisone or prednisolone. Symptoms of adrenal insufficiency may include fatigue, hypotension, hypoglycemia, and abdominal pain. Monitor adrenal function regularly and consider adjusting corticosteroid dosages as needed.

3. Fluid Retention and Edema:

• Xbira may cause fluid retention and edema, which can exacerbate existing conditions such as heart failure or hypertension. Monitor patients for signs and symptoms of fluid retention, including swelling in the feet, ankles, or hands, and manage accordingly.

4. Hypertension:

• Xbira can cause hypertension (high blood pressure). Blood pressure should be monitored regularly during treatment. Antihypertensive therapy may be required or adjustments made to existing antihypertensive medications.

5. Cardiac Disorders:

• There is a potential risk of cardiac disorders, including heart failure and atrial fibrillation, particularly in patients with a history of cardiovascular disease or risk factors. Monitor cardiac function and manage cardiovascular risk factors appropriately.

6. Bone Health:

• Xbira use may lead to a decrease in bone mineral density and an increased risk of fractures. Consider bone density testing and use appropriate interventions to minimize the risk of skeletal-related events.

7. Pregnancy and Breastfeeding:

• Xbira can cause fetal harm if used during pregnancy. It is contraindicated for use in women who are pregnant or may become pregnant. Advise male patients to use effective contraception during treatment and for at least 3 weeks after discontinuation. It is not known whether Xbira is excreted in human milk, so breastfeeding is not recommended during treatment.

Frequently Asked Questions

1. What should I do if I experience severe side effects or allergic reactions while taking Xbira 250mg Tablet?

Ans. If you experience severe side effects or allergic reactions such as difficulty breathing, swelling of the face or throat, or severe dizziness, seek immediate medical attention or contact your healthcare provider.

2. Are there any food or drug interactions with Xbira 250mg Tablet?

Ans. Xbira can interact with certain medications, including corticosteroids, anticoagulants, anticonvulsants, and drugs metabolized by CYP3A4. It’s important to inform your healthcare provider about all medications and supplements you are taking.

3. Can I drink alcohol while taking Xbira 250mg Tablet?

Ans. It is generally recommended to avoid alcohol while taking Xbira, as it may exacerbate certain side effects and affect liver function.

4. How often do I need to have medical tests while taking Xbira 250mg Tablet?

Ans. Regular monitoring is important while taking Xbira. This includes liver function tests before starting treatment, every two weeks for the first three months, and then monthly thereafter. Blood pressure, adrenal function, and other parameters may also be monitored as needed.