X trant 140mg Estramustine Phosphate Capsule

Introduction to X trant 140mg Estramustine Phosphate Capsule

X trant 140mg capsules contain estramustine phosphate, a unique medication that combines a hormone (estrogen) with a chemotherapy agent (nitrogen mustard). This combination offers a dual mechanism of action, making it effective against certain types of cancers, particularly advanced prostate cancer.

Estramustine phosphate works by interfering with the growth of cancer cells, inhibiting their replication and inducing cell death. Its estrogen component targets hormone-sensitive prostate cancer cells, while the nitrogen mustard component acts as an alkylating agent, damaging the DNA of cancer cells and preventing them from dividing further.

X-Trant 140mg (Estramustine Phosphate) Capsules are indicated in the palliative treatment of patients with metastatic and/or progressive carcinoma of the prostate. X-Trant 140mg (Estramustine Phosphate) Capsules has anti-tumour properties and it improves patient outcomes if combined with other chemotherapy agents such as docetaxel.

It is used to treat prostate cancer that has worsened or has spread to other parts of the body.  It works by stopping the growth and spread of cancer cells. Since this medicine is used to treat male prostate cancer, it is not indicated for women.  Do not take Estramustine if you are allergic to Estramustine or any other ingredients of this medicine.

X-Trant 140mg (Estramustine Phosphate) Capsules is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body.X Trant 140mg capsule contains the active substance estramustine. It is an anti-cancer medicine that belongs to the class of medications called microtubule agents.

X Trant 140mg capsule is an antineoplastic drug with the effects of estradiol and nitrogen mustard combination. It may inhibit tubulin function by binding to microtubule proteins. Antitumor effects may result from estrogenic effects. Plasma testosterone levels decrease while estrogen levels increase.

What is the Use of X trant 140mg Pills?

X trant 140mg capsules, containing estramustine phosphate, are primarily used in the treatment of prostate cancer, specifically in cases where the cancer has spread or is resistant to other treatments. Here are the key uses of X trant 140mg pills:

• Advanced Prostate Cancer
• Hormone-Sensitive Prostate Cancer
• Chemotherapy
• Treatment Resistance
• Combination Therapy

How Does X trant 140mg Estramustine Phosphate Capsule Work?

X trant 140mg capsules contain estramustine phosphate, a unique medication used primarily in the treatment of advanced prostate cancer. This medication combines an estrogenic component with a chemotherapy agent to exert its therapeutic effects through a dual mechanism of action.

The estrogenic component of estramustine phosphate acts by binding to estrogen receptors on prostate cancer cells. Prostate cancer cells often rely on androgen hormones (such as testosterone) for growth. By mimicking the action of estrogen, estramustine phosphate competes with these androgens, thereby disrupting the signaling pathways that promote cancer cell proliferation. This hormonal interference helps to slow down the growth and spread of hormone-sensitive prostate cancer.

The combination of estrogenic modulation and chemotherapy in X trant provides a synergistic approach to targeting prostate cancer cells. This dual-action mechanism makes X trant particularly effective in cases where prostate cancer has advanced beyond the prostate gland or has become resistant to other treatments. By disrupting both hormonal signaling and cellular DNA integrity, X trant aims to reduce tumor size, alleviate symptoms, and potentially prolong survival in patients with advanced prostate cancer.

Side Effects of X trant 140mg (Estramustine Phosphate Capsule)

X trant 140mg capsules, containing estramustine phosphate, can cause several side effects, some of which can be significant. It’s important for patients and healthcare providers to be aware of these potential adverse reactions:

• Gastrointestinal Effects
• Estrogenic Effects
• Cardiovascular Effects
• Hematologic Effects
• Ocular Effects
• Allergic Reactions

Drug Interactions

X trant 140mg capsules (estramustine phosphate) can interact with several medications, potentially affecting their efficacy or increasing the risk of side effects. It’s crucial for healthcare providers and patients to be aware of these interactions to ensure safe and effective treatment. Here are some important drug interactions involving X trant:

• Anticoagulants (Blood Thinners)
• Anticonvulsants
• Corticosteroids
• Digoxin
• Lipid-lowering Medications
• Herbal Supplements and Over-the-Counter Medications

Manufacturer

X trant 140mg tablets is manufactured by Natco Pharma. It is an Indian multinational pharmaceutical company based in Hyderabad. Natco Pharma Limited was established in 1981. The company manufactures finished dosage formulations active pharmaceutical ingredients and Agro chemical products.

Storage

Dosages

The dosing regimen for X trant 140mg tablets (estramustine phosphate) is typically prescribed based on the specific condition being treated, the patient’s health status, and their response to the medication. X trant is primarily used in the treatment of advanced prostate cancer, where it combines estrogenic and chemotherapy effects to target cancer cells.

For the initial treatment of advanced prostate cancer, X trant is often initiated at a dose of 14 capsules (140mg) daily for the first 30 days. This initial high dose is intended to achieve therapeutic levels quickly and start controlling the progression of the cancer. Following the initial phase, the maintenance dosage is usually reduced to 7 capsules (70mg) daily

Dosage adjustments may be made by healthcare providers based on the patient’s tolerance to the medication and their individual response. It’s essential for patients to adhere strictly to the prescribed dosage regimen and follow-up appointments with their healthcare provider for monitoring and adjustment as necessary.

Warning And Precaution

X trant 140mg tablets (estramustine phosphate) carry several warnings and precautions that patients and healthcare providers should consider before and during treatment. These are important to ensure safe and effective use of the medication:

1. Ocular Toxicity: 

• Long-term use of X trant may cause ocular toxicity, including changes in vision, blurred vision, or difficulty focusing. Regular eye examinations are recommended during treatment to monitor for any signs of ocular damage. Patients experiencing visual disturbances should notify their healthcare provider promptly.

2. Cardiovascular Risks

• X trant can increase the risk of cardiovascular events such as blood clots (thromboembolism) and hypertension (high blood pressure). Patients with a history of cardiovascular disease should be closely monitored during treatment. It is important to weigh the potential benefits of X trant against these risks, especially in patients at higher cardiovascular risk.

3. Hormonal Effects

• Due to its estrogenic component, X trant may cause hormonal effects such as breast tenderness or enlargement (gynecomastia) in males. These effects are usually reversible upon discontinuation of the medication but should be monitored during treatment.

4. Fluid Retention

• X trant can cause fluid retention, leading to swelling (edema), particularly in the legs and ankles. Patients should monitor for signs of fluid retention and report any worsening symptoms to their healthcare provider.

5. Liver Function

• X trant may affect liver function, leading to elevated liver enzymes. Liver function tests should be monitored periodically during treatment, especially in patients with pre-existing liver conditions.

6. Pregnancy and Breastfeeding

• X trant is contraindicated during pregnancy and breastfeeding due to potential harm to the fetus or infant. Women of childbearing age should use effective contraception during treatment and for a period afterward as advised by their healthcare provider.

7. Special Populations

• X trant should be used with caution in elderly patients and those with renal impairment. Dosing adjustments may be necessary based on individual patient characteristics.

Frequently Asked Questions

1. What are the precautions I should take while using X trant 140mg tablet?

Ans. Patients should adhere strictly to their prescribed dosage and schedule, attend regular medical appointments for monitoring, and report any new or worsening symptoms to their healthcare provider promptly. They should also inform their healthcare provider about all medications, supplements, or herbal products they are taking to avoid potential interactions.

2. Are there any specific drug interactions with X trant 140mg tablet?

Ans. Yes, X trant can interact with several medications, including anticoagulants, antiplatelet agents, hormonal therapies, and certain chemotherapy drugs. Patients should inform their healthcare provider about all medications they are taking to prevent potential interactions and adverse effects.

3. What should I do if I miss a dose of X trant 140mg tablet?

Ans. If a dose is missed, patients should take it as soon as they remember. However, if it is almost time for the next scheduled dose, they should skip the missed dose and continue with their regular dosing schedule. Doubling up on doses should be avoided.

4. Can I drink alcohol while taking X trant 140mg Tablet?

Ans. It is advisable to avoid alcohol while taking X trant 140mg Tablet as it may increase the risk of certain side effects. Consult your doctor for specific advice.